[00:07 - 00:45] Today I'll be talking about autism. Most of the material I'm going to share with you today I actually have had for a long time. I originally gave this presentation at New York University when Mary Holland was still there and it was met with some questions by some people in the audience and other people seem to forget it. I had numerous people stop me on the way out saying that it was very convincing. So in terms of playing the expectations game Yeah, let's see. [00:45 - 01:54] For today I titled it We Know the Causes of Autism, It's Time to Act Accordingly. I'm going to go over about six different topics on autism. Those particular topics are key and central. You may have heard of some of them, you may have heard about problems with vaccine safety science, and that kind of thing, but there's really a systemic issue on the question of autism that causes complete misunderstanding from a legal standpoint, from a genetic standpoint, you know, scientific, medical and legal standpoint, regulatory standpoint, all of it, is completely backwards to anything that I would have expected. You know, I became an expert in autism by reading 2,000 studies, I had downloaded 3,000 studies just to find out what autism sorry, just to find out what autism was when I had found that the science that the CDC was conducting and contracting was not anything like I would have expected. [01:54 - 02:53] I was expert in, I'm expert in multivariate and complex data analysis in biomedicine. I was the director of the Bioinformatics Analysis Corps until 2014. About that time, the University of Pittsburgh and I parted ways, somebody found my supercomputer and wanted my shop, I had a research core there, I was not protected under tenure, I had stepped on to a staff member to conduct a 100 studies for researchers at the University of Pittsburgh, design the studies with them, design the approach to analysis, conduct the data analysis with my staff. So I have experience in biomedicine, the Department of Pathology for three years, four years. I was in the University of Pittsburgh Cancer Institute and everything that I had learned by the immersive experience, you know, brought in $27,500,000 to library funding, Everything I knew about objective science that I've been trained in my PhD seemed to be violated in the vaccine studies. [02:53 - 03:30] So today's talk is not going to be so much about vaccines. I have a report I can share with you that completely demolishes the studies that we saved during his first tenure, were sent to President Trump saying, look, we have the studies that show the vaccines don't cause autism. They can't say that because not all vaccines have even been tested or studied for association with autism. Association doesn't test causality, but today what we're going to talk about is, we're going talk about what we know about autism. We're going to talk about the false binary, genetics versus environment. [03:30 - 04:06] I'm going to give you some scientific insight into some of the autism research. I'm going to show you that they've been playing games with genetics, at least make the argument. I'm convinced based on what they've done that they're playing games with genetics of autism. Now I'm going to talk about bona fide contribution of genetic risk to autism, what I think that risk represents. I'm going to show you the claims of high heritability or faults that's consistent with game playing with genetics, but it's not the same thing. [04:07 - 04:50] Give you some, you know, common ground on the fact that you can have the same kind of disease under the moniker autism from multiple causes, both genetic and environmental. And so it's non sequitur to say genetics or environment in any way if you're talking about the population. I'm talk about why it's so common maternal immune activation, genetic and environment interactions, which are profound and you know, these are some of the topics, risk stratification and so on. We should get underway. This is I'm not going use every slide in this deck, I apologize. [04:51 - 05:45] These are the people that got me started early on when I first started I PAC, Mary Anne Flood, Mary Holland, Ted Fogarty, and others. And these individuals are had faith in me to help help me get I PAC launched as an institute to do independent research. I now have thousands and thousands of people that I could put on these slides, but these are great people and I wanted to appreciate them. So I'm a biologist, an evolutionary biologist, systems biology expert, complex systems dynamics expert, cancer biomarkers researcher, bioinformatics expert. I can design studies like anybody, I can analyze data of many different flavors, I'm a modeler at different levels of proficiency, and I founded IPAC so that independent research could survive what I saw was bias in Internet era I saw it coming. [05:45 - 06:34] And '20 I think it was 2015 I wrote an article, The Farmables are Loose, It's the End of Democracy in America. No one was talking about the end of democracy back then. I created ipacedu.org, ipac.org, I have over 30 instructors with 60 courses. This is part of building the parallel institutions that are necessary when there is a legitimacy vacuum and to empower individuals so that they can speak truth to power, they have the technological ability to, technological knowledge to talk about things like maternal immune activation, autoimmunity, the role of aluminum in animal studies to routinely and reliably induce autoimmunity. We have over 60 courses, we've had over 4,000 participants, and, I also want to talk about, my journal, Science, Public Health Policy and the Law. [06:34 - 07:02] Some profoundly fundamental papers were published there. We published Jessica Rose's paper that showed that most of the events that happened, deaths in particular, following vaccination happened on day two and day three. That was not the null expectation, you know, if there's no cause causation, Robert F. Kennedy Jr. Actually cited the journal twice, one during his nomination, another time when he was being confirmed. [07:02 - 08:12] So, yeah, we we published studies after rigorous peer review. I want to just step through what I call the IPAC ASD causality model. This is backed, every single arrow in this, you can find this on the website, I'll show you the link, but every single arrow in this causality model is backed by studies of the literature. Taken all together, this also reflects my understanding after reading thousands of papers on autism, I turned to the mechanistic literature because if CDC was cheating and analyzing the data once, throwing the results away that they didn't like the result because it did show an association, analyzing it again, changing the subgroups, you know, changing the method of analysis, dropping people for arbitrary reasons so you had lower statistical power so you couldn't find the effect of vaccines in autism, hiding the effect of vaccines by only studying vaccines and never bringing in genetics and not looking at the genetic by environment interaction term and those kinds of things. In the genetic side, just always just studying genetics and never looking at environment, we had a problem. [08:12 - 09:25] The problem was maybe CDC is a bunch of good guys and they were actually hiding the risk because the risk was so minimal that they should do that and it could harm the public if they found out about it. Or maybe there is a wealth of information in the mechanistic literature. When I went to the literature, simply wanted to find out what people were saying from all kinds of studies, cellular studies, animal experiments, human studies on the pathophysiology of the disease that we call autism, and I won't step you through this whole thing, but I will center in on ER hyperstress in the center here. You notice there are multiple arrows that are pointing into ER hyperstress from the toxins that are absorbed in the lower right, multiple chemical sensitivity, you could also argue that's toxicity, direct mitotoxicity, and then you also have genetics, genetic variation causing unfolded proteins in the cell, that if you have too much unfolded protein because, you can't fold them properly, the cell swells up and there's there are two proteins on the surface of the cell that open up, and those proteins actually tell the cell it's time to resolve this, shut down transcription, shut down translation or die. [09:26 - 10:45] That's the unfolded protein response and the paper that was sent around with the presentation announcement is a paper where I tested the hypothesis actually of the unfolded protein response, because I predicted that genes that were being found to have some association with vaccines, none of which explain more than you know, one percent of autism, that they would be disproportionately found to be the types of proteins that have to be folded in the endoplasmic reticulum using energy. A lot of our proteins just in their native confirmation are the appropriate folded, optimally folded functional protein. I think it's two thirds of them, are like that, about about a third of them have to be folded. So I did a hypergeometric test or something like that on that, the p value was highly significant that among the genes that are found associated with autism risk, even though none of them individually explain more than one percent, we have a problem where just almost any protein that you can't fold, easily if you have a genetic variation, and then if you impair and cause ER stress through aluminum or mercury or other toxins, so you might have imagined a suite of environmental toxins that are known to cause ER stress, then you have a problem, you have a compounded risk of ER hyper stress and cell death. [10:45 - 11:44] Among the most noxious of these toxins stay in the cell and they will kill that cell by causing this, it's like a seepage of cell contents, it's necrotic cell death, it's not apoptosis. And so then what's released through the ER hyperstress response is a bunch of improperly folded antigens that are almost human like because they're not properly folded, and that could set you up for immune reactions, and by the way, there's a nice aluminum adjuvant of its adjuvant right attached to it and oftentimes are near it. And so this is multi compartment and if you go to the website, you can see all the papers that I based this on, each paper there is, you know, peer reviewed, each compartment is backed up and you can see this. Now, how does this work in the brain? In the brain we end up with chronic microglial activation because the cells that are dying, any cell in the brain that's impacted by aluminum will die. [11:46 - 12:22] You end up with cellular debris and it seems the brain is on fire. It seems like there's a chronic persistent viral infection. The microglia cannot be available to do proper pruning during neurodevelopment. The microglia cannot be available to do proper hand holding to make synapses because they do, they play multiple roles. If the microglia are too busy cleaning up what they think is something like, and I use think as a euphemism, but the shorthand, but they think that the brain has a chronic viral infection or is consistently injured. [12:23 - 12:44] It's very dangerous to get multiple concussions. It's very dangerous to get encephalopathy from viruses repeatedly. It's very dangerous to get encephalopathy from vaccine models and others and other bounds. I've written three books. They're published in succession, quick succession, Ebola, an evolving story, cures versus profits. [12:45 - 13:03] The middle book is the one where I fell down the rabbit hole, so to speak, on vaccines. I literally wanted to write a chapter showing that vaccines were safe, vaccines were effective, and everything was super with vaccines. I wanted to celebrate vaccines. And when I made those claims, of course, if you read the rest of my book, I can't just say that. I have to go to the literature and look at the studies. [13:03 - 13:46] So I went to look to the studies and back up the things that I thought I was going to say, and the floor fell out from underneath me. I could not find the science that showed the vaccines do not cause autism because they didn't study all vaccines. I could not find that the science, the studies that they did do say on the MMR done appropriately and objectively. Instead, I ran into the VSD study by Thomas Restraton, where they found a linear association between the all mercury exposure to date from vaccines and autism, and that they had spent four years trying to manipulate the data to try to make the association go away. I found, that someone had FOIA ed the US government and they found an email from Tom Verstraighten saying it just won't go away in the name of all things objective. [13:46 - 14:02] I don't want to sound like an anti vaxxer, but we should publish this. But then somehow magically, they found a way to make the association go away and publish that final result. They didn't publish the interim results. The only reason why we know about that is because of FOIA. And then I also found this is before the Vaxx film. [14:02 - 14:55] I found William Thompson's transcript with a guy named Brian Hooker from Simpson University in California and I was floored. Not only did they falsify the data that they presented to the IOM and leave out key results about increased risk of autism, in African American kids, boys in particular, if they got delayed MMR versus on time MMR, The people that kids that got on time MMR had higher autism risk. But they also Bill Thompson also told Brian Hooker that every single vaccine study that's published by or contracted by the CDC goes to a sanitation committee that reads the study to the report to make sure that there's not scary language in there. That didn't sound like Simons to me. Come to find out, Brian Hooker loved to talk about this stuff. [14:55 - 15:23] I interviewed him, and he's quoted in this book. I interviewed him for about three hours. Well, he had talked with Bill Thompson for a large number of hours and the fact that they had a sanitation committee was just the one it was that was the spot that broke the camel's back for me. If I had done this kind of science while I was at the University of Pittsburgh, would have and should have lost my job for performance. So there's some caveats, you know, I'm paid to do my job like other people. [15:23 - 16:32] I collect money from the public to do research. I'm no longer associated with the National Vaccine Injury Compensation Programme, they tried to bribe me to change my testimony about aluminum, I would not, and I have the recording for that. I decided to leave that programme. We actually have no intellectual property that's generated at IPAC that we can commercialize, it's built into our domain, but now I teach courses at IPAC edu and we process paper, you know, publication fees and so on for the journal, it's all fair, bills keep coming. So, we've seen the rates have increased at this time it was one to sixty eight, now we're looking at one to thirty six, this is very damaging to our confidence that there's not an increase, there is an increase, and the fact that CDC bent over backwards administration after administration after administration to hide, the increase in autism, let alone the association of vaccines in autism, really speaks to the length to which they will cover up data that might cause people to be afraid of vaccines, and thinking that they're doing their job. [16:32 - 17:30] In my book, The Environmental and Genetic Causes of Autism, I, you know, spoke with experts who do autism diagnosis every day, I read the DSM-five, we were transitioned from DSM-five to DSM-four to DSM-five, and they combine the social and communication domain into one of the characteristics, it used to be two out of three of those characteristics, so if you read older autism papers, what they're calling autism in the older papers is not the same as what they're calling now, because it's no longer two out of three. When you change a diagnostic rule like that, that can have a profound effect on numbers, I'll grant you that, but when you combine social communication domain and restrictive repetitive behaviours and that's enough to give a diagnosis of autism, I'm not sure what the effect is. Two out of three might be better, might be worse, I don't know. I'm not going spend too much time here, but I did try to understand regressive autism, it's all broken down in the book. Yeah, so let's talk about how they have been playing games with genetics. [17:32 - 18:10] Let's see, the organisation Autism Speaks funded a lot of genetic studies and the goal here was to try to find genes through genome scans that were associated with autism, and every person that they funded found different genes. Were over 850 genes that were found. They might this one, this team found 20, this team found 50, whatever. They all found different genes, and no individual gene accounted for more than 1%. You would think that they were the neuro neurologic genes, the synaptogenic genes, synaptic proteins and so on, neurotransmitter processing receptors. [18:12 - 19:02] It was all over the place. And this list got so big that right after I published my book, they decided that they were going to go through and pick the 50 most likely candidates, none of which explain more than 1%, to say these are now the new autism genes and then they funded more studies to discover new autism genes. That's what I mean they're playing, like so that you can get another headline in the news that says scientists found another gene associated with autism. They really abused the publication, the research publication news cycle at that time. About twenty percent of people with autism diagnosis have higher copy number variations, which tells me that there's something going on probably with, you know, replication, genome replication, methylation, and de novo mutations are important as well. [19:02 - 20:00] There's a large number, larger number in excess of de novo mutations, so we really don't know why. But, they found that, regulatory genes in early development seem to be implicated somehow, but it's worth remembering that synaptogenesis occurs prolifically throughout brain development, but it actually occurs throughout life. A lot of the studies, you know, early studies confuse familial and genetic risk, you know, there's a difference there and for all these genes, they would say there's every kind of mode of inheritance you can see dominant recessive complex and it didn't make any sense. And Pinto is a great study if you're into quantitative stuff, I'm going to bring you right up to Pinto here. In this study, they looked at how many genes have to have a mutation in them, and what percentage of subjects are where you have multiple genes. [20:00 - 21:27] This is the multi hit hypothesis, and it turns out that between the effectives and controls here, this is the predicted OR in our model. Yeah, this is the empirical as well. I forget which is which, it's been a long time, but you can look up pintle at all, but it turns out that while yes, you can get autism by getting mutations in two, three, four genes at the same time, the probability of those genes coming together in the same person in the population is so small, it can't possibly explain the risk of autism. It can't possibly go anywhere near explaining the risk of autism, and so what's really happening here, I put this chart together from data, you have common variants that seem to be shared with people without autism, you have other variants that are unique to autism, and you have rare de novo, which is a small percentage, but it's still in consent, and then you have what they call ASD risk. The ASD risk are the ones that they're talking about, so it's a tiny percentage of genetic liability that's attributed in the genetic studies, and I have to go back to the genetic studies here and show you that when you say something like autism that has the characteristics of repetitive behaviors, the degree of sociality and language use and that kind of thing, that there is a heritability for every single trait that's ever been studied in humans. [21:27 - 21:52] So even without autism, these have a heritability. So you kind of have to look at the increased heritability over the heritability and these traits, is it special, is it unique? No, these traits are heritable. So just finding that these traits are heritable doesn't make the disease or the condition itself a genetic disease, right? It's like saying, well, my son has eyes because I have eyes. [21:55 - 22:55] And one of the first things that I noticed was that valproic acid is known without any controversy to cause autism. So when people say nobody at the time, people saying nobody knows what causes autism, it's not environment, it's genetics, they forgot about valproic acid, but there's also this thing called phenomimicry where you can have some mutations that occur that affect say, neurocrest early development in the gene CHD seven and eight, and you have loss of function mutations of those genes, it has the same exact phenotype as valproic acid. So to say genetic versus environment, when we know you can get to the same effect via either mechanism is really irresponsible scientifically, it's irresponsible clinically, we should be wondering about the genetic environment interactions. These kids that have or they're born with mutations that make them prone to have autism, then get exposed to toxins that do not cause autism in everyone. That's what's tipping them over. [22:56 - 23:48] Mutations in the plasma reticulum genes, thimerosal itself inhibits ERAP1. ERAP1 is responsible for proper protein folding of antigens to present on the surface, well, if it happens in the immune system, it's happening elsewhere. We know that there are people that have mitochondria mutations that lead to an autism diagnosis, and then we can also see glyphosate induced mitopathy. So the mitochondria aren't functioning well because of an environmental function or because of mutations, tell me which one is exclusion of the other, neither one excludes the other. And yeah, I can go on with this, there's a list of them, but if you look at synaptic development from conception to nine years, particular regulatory changes that are important, CHD7, CHD8, so those would affect there. [23:49 - 24:59] Zero to two years, synaptogenesis is important there, but you end up with the expression of serotonin receptors, the development of particular pathways in the brain through pruning, reinforcement, and one of the things about the autistic brain is that it has long range connections that are not supposed to be there. Those connections make pathways that make people more susceptible to seizures. It makes them sensitive to light and sound where I think it can even push the sensory neural activity into the motor cortex causing them to react in ways that they can't necessarily control. When I tell this to groups when I speak in public, I talk about how the microglia are not available to do that pruning, and so when a door slams and they react, they can't handle the sound or when a fan is going and they're fixated by it or they can't tolerate that. If they can't, if they don't have proper inhibitory shutdown of the neuro, of the pathway, and they have long term pathways, we can't tell, it's unpredictable what's going to happen to how they have to react to it. [24:59 - 25:29] And by me telling them that they can't help themselves, lot of the moms are just, they break down in tears. They're like, why didn't our doctors tell us this? Because they think it's something that they're doing, but they can't necessarily control it. We know that motor neuron development is very important for articulation and speech and fine motor movement, and we know that kids with autism suffer terribly from having an inability to do fine motor movement. So, you ask them to do something with their hands, can barely do it, many of them. [25:29 - 26:44] And so, the spellers program, they start teaching them to spell by pointing and they can use their shoulder to point at a spelling board and then they bring the board, it's a huge board, and then they bring the board down and they refine their motor skills so they learn that and learn that pathway until they're working on a keyboard, and so they have enough fine motor skill to do that, and so the brain can be trained to overcome some of that neurodevelopment that was missed for motor skills, but some of them are very difficult to overcome, and you hit them with vaccines right at the time when you're undergoing gliogenesis, you're at the tail end of neurogenesis itself, but synaptogenesis is just starting myelination for proper regulatory control of different parts of the brain. Did you know that our brains produce more transcript products of diverse types than any other organ that we have, and then if the microglia then if they have metals in the brain and they're constantly, constantly distracted, they're not available, it's called chronic microglial activation and that lasts according to Parvo in the literature, from the age of five to 25, then they're not available to do the synaptic pruning that's necessary throughout life, and so there's an altered development all the way through. [26:45 - 27:21] This is a slide that was made by Andre Ankel and Tony. Yeah, so we know the transcriptional programs that are altered and how they fit on the timeline. It's devastating to impact them as they're trying to develop their brains. It's It's devastating to impact these and change these programs. There's been genomic studies on kids, the chronic microbial activation by the way was found in kids that died from other causes from the age of five to 25. [27:23 - 27:46] Yeah. Like I said, I'm gonna skip over some of it, but when it this says latest, but this was back in, you know, 2016 when I put the slides together. The largest oh, said largest. Largest genetic studies, Hallmeyer and Sandin, they didn't measure any environmental factors. They didn't estimate genetic environment interactions, but they both nevertheless concluded that autism was about 50% environment and 50% genetics. [27:46 - 28:40] That is they looked at their heritability estimates and they couldn't, they said there was enough room here for 50% of environment. So when we have people like Peter Hotez, who most recently came out and said that there is no environmental component, if it does happen, it happens in the earliest stages of life, it happens to the fetus in utero, and he doesn't go on to say chronic micro chronic maternal immune activation, whether it's from a virus or whether from a vaccine is dangerous for brain development of the fetus. It is it doesn't go on to tell you all about the neurodevelopment that takes place after birth. That's just propaganda and is woefully, irresponsible. And he actually won a a political cartoon on popular rationalism, about substack.com yesterday. [28:40 - 28:52] We just published a paper there crit critiquing him. He was, cited by MedPage today saying that there's nothing to this. We have massive amounts of evidence now. We do not have massive amounts of evidence. He's outright lying. [28:53 - 30:03] Like I said, not all vaccines have been studied, and the ones that have been studied have been cooked, to death. So I I went into detail, and after I published my book, then they started doing genetic studies that somehow the heritability estimates kept increasing and increasing and increasing, edging out environment. It's just amazing what you could do with science if you want to, but you can't change this. If you look at where autism is on a pedigree, and this is one of the largest pedigrees for a family with lots of autism penetrance, none of the aunts and uncles have had autism, none of the parents had autism, it's this to me looks like humanity dipping their fingers or their feet I should say into the toxic soup that we have from the chemistry corporations and other corporations that make toxins in our environment. There's a huge list of toxins that can cause endoplasmic reticulum stress, and then okay, don't remember what that's about, but this shows that most genetic risk for autism, this is just a resides with common variation. [30:03 - 30:45] So if you're looking for autism genes, there there's just common variation that doesn't cause autism in a lot of people, and yet somehow these proteins are the ones that are contributing to autism. It's heterogeneous, right? That's why the paper is that autism is an acquired cellular detox ification deficiency syndrome with a heterogeneous genetic disposition. If you have broken proteins, there's a lot of ways to sabotage the brain cell and make it die, and there's a ton of proteins in the brain that are expressed the largest number of transcript products. So you simply have normal genetic variation and as a diploid organism, you know, you have mom's copy that's working or dad's copy that's not working. [30:45 - 31:31] Usually what happens is the cells that express too many variants that, you know, too many copies of proteins that don't fold properly, you get an endoplasmic reticulum stress and that cell lineage dies. It's not just that one cell that dies, it's the entire cell lineage. So we're kind of are pruning ourselves just by cell death through the ER stress response to express the combinations and the genotypes in cells through recombination, through methylation, so on, that allow that cell to produce a healthy functioning liver cell, kidney cell, whatever it is, in this case, brain cell. And so we're all experiencing endoplasmic stress just due to genetics. That's the message, now it must be that environment is adding more into plasma reticulum stress. [31:32 - 32:22] Aluminum hydroxide is used to routinely and reliably induce autoimmunity in animals, so that the drug companies can create drugs to treat asthma and demyelinating diseases and rheumatoid arthritis and autoimmunity of the salivary glands, Sjogren's syndrome. So, you know, we're looking at a complex heterogeneous risk, where the risk is really whether you already have some unfolded proteins in the cell, that's my model, and then you add the environmental insult to that. Aluminum actually gets when it gets into the cell, it actually goes to the nuclear pore and gloms up all the proteins. The endoplasmic reticulum actually gloms up. It's so caught up with sticky sticky proteins. [32:22 - 32:53] It it gloms up against the nuclear pore. When you put thimerosal on an astrocyte, this was, I think, back in 1946, a Japanese researcher did it, looked into the microscope, the ER disappeared. So it's the same thing. It's causing the ER not to be able to function properly for these proteins that have to be used. So I think we need to look at older siblings versus younger siblings, where the younger siblings are not vaccinated because the parents reacted to it and the older siblings are. [32:53 - 33:42] I'd like to see twin studies as well, but when you want to really understand causality and whether genetics is causing it, you're supposed to take twins that have the risk and twins that don't have the risk and give the exposure to one of the twins. But in this case, all the twins are vaccinated, so it's hard to do that kind of thing. So if you if you remove the exposure from one of the twins, and then you see that the exposed twin got it, then you can say, well, it's more than genetic. You can't say it's not genetic, but you just say it's more than genetic. In some cases, literature back then supported a one to one correspondence, and you can read these studies, they're cited in my book, organophosphates and PON1 gene, pregnancy related stress and the ADRB2 gene, traffic related particulate matter and the MET gene, peri conceptual maternal prenatal vitamins. [33:43 - 34:31] If you have MTHFR and CBS and COMT, you're going be in trouble probably because of the folic acid, you should have methylfolate. So these all came from a review by Bowers and Erickson in 2014, gene environment interaction in autism spectrum disorder. The right kind of study to do is to of course look at genetic risk and look at heritability, but then bring in exposed and non exposed and then see what the interaction term is, you have to design that study properly. There's a whole bunch of other evidence that I won't go into, we don't have time to go through the detail, the book is chock full of it and if you look at specific G by E vaccines, you have the sodium channel, SCN one a variation associated with sensitivity to vaccine induced encephalopathy. That's good enough for me. [34:31 - 35:04] If you have a genetic variation that increases the risk of vaccine induced anything, then you've shown genetic by environment interaction for that person, for that group, whatever, family. MTHFR certain MTHFR mutations increase thimerosal susceptibility. Thimerosal is just more toxic for these people. So kids who have autism, they they have a hard time detoxifying. So why do we expect vaccines or anything else that like organic pollutants in their home to to be equally safe for them? [35:06 - 35:51] Yeah. This this is a combination of things already said. But if you look at the autism risk genes themselves, these are the ones that you look at and you say these, if you have two, three and four of them, you could develop just purely genetic autism, each one of them is less than one percent of the risk. The environmental susceptibility genes that are reported in those eight fifty genes are about 40 to 60% of that, and I called them, I made this term of the autism phenotype modifier genes, where they make communication skills and apparently intellect worse, because those communication skills and intellect are not part of the autism diagnostic criteria actually. This is one of my favorite studies of all time, and this is what's happening even now. [35:51 - 36:31] People that are retiring, like, what's his name, from the CDC, but his name will come back to me. He did an aluminum and asthma study. Bill Thompson was was was his colleague. Anyway, just before leaving CDC, he Di Stefano, Frank Di Stefano, published a study that showed that there's an increased risk of asthma with the increased amount of aluminum that you receive as a child from vaccines. Well, no kidding, we use aluminum hydroxide to induce asthma in rats and mice with no other antigen source, just ambient antigens in the room will give them asthma. [36:32 - 37:33] I reversed my own asthma by doing aluminum detox on myself with a low slow protocol that I put together by doing a lot of research on it, but this study was great. So this this was a mouse study, people will, you know, say can mice get autism? Well, can, they certainly have habits. If they stop vocalizing, if they don't recognize other mice, if they have habits, repetitive motion and all the rest, you can pretty well say that they have autism like symptoms. And so the genetics were a CN Ttap-two mouse, and they found that males in particular, if they were challenged with maternal immune activation with lipopolysaccharide and bacterial infection, that the males would develop with three hits genetics, lipopolysaccharide and bacterial infection, they would develop severe severe, phenotypic responses like this, with a greater frequency. [37:33 - 37:45] There's a gender bias just like in humans. Isn't that fascinating? This guy did the Shafma in some place in New York. I think it was New York University. He did this in PNAS just before he retired. [37:45 - 38:02] Isn't that fascinating? So how long did he know this? You know, like, people are trying to get the word out. Yeah. So if if you if you forgive me for this because I actually don't recall the point of having it in there. [38:06 - 38:51] But if you look at just the loss of function genetic aspect of autism, of course if you have FOXP2 mutations, you're going see speech and language difficulties. There's a p10 modifier of microglial activation itself. Microtube processes a nerve cell function clustering around the gene spasm, so there are genes that we could point to that say, hey, you can get this exact same kind of problem or similar problem, at least to the general, the macro phenotype, but if you drill down to the cellular level, they're very different. Microchronic microglial activation is basically brain wide. There's differences in the pyramidal cells, they're simplified in the, complexity is is not as profound. [38:51 - 39:17] It's still there. There's still more complex than neonates, but there's just a problem with it. So if if if you really wanted to drill down to the neurobiology of this, you could make the case that we could get there through genetics, but we could get through through genetics due to the complexity of bio pathways many, many different ways. Right? So you could get through through changing your methylation. [39:18 - 40:41] Well, in methylation is another way that the environment can impact gene expression. And so, yeah, I organized all the genes that were reported to be the highest frequency in autism according to their ASD or ASD associated phenotypes, so that we can, you know, maybe look at some of these and say which ones do we want to look for with mutations and say these kids are at higher risk. So if we're going to screen, it wouldn't just be screenings like for autism genes, it would be screening for genes that also then tell us that they can't tolerate toxins as well for two reasons. There's mutations in the detoxification genes themselves, that's what most people think about, but mutations in critical genes that are responsible for certain brain function are really important because that compartmentalized endoplasmic reticulum risk exists in the brain and that's what we're trying to protect. So the literature supported at this time, aluminum mercury acetaminophen after high fever and MMR vaccine, MSG, thalidomide, valproic acid, congenital rubella infection, glyphosate, PDVEs, air pollution, phthalates, ultrasound exposure, there's some evidence that that might be playing a role here, and inorganic solvents if the parent was exposed. [40:42 - 41:47] Mark Blacksow and Dan Olmstead were working together on a project called where where where they tracked down from Leo Kanner, the the in in real life, they tracked down the people who were descendants or still living relatives of the very first cases of autism. And in every case, a parent had a mercury exposure. One of the dads of one of the more famous ones, because there was a picture of the kid, the kid had microcephaly, it's the most famous picture of microcephaly in autism research ever. He actually worked in the timber industry and there was a preservative that he worked with on a daily basis and that had a mercury component to it, and he would bring that home is the argument. And so, know, if you look at adults in the Minamata exposure from Minamata Bay, who are perfectly functioning adults, and you look at their patterns of behavior, they don't recognize people in the room, they don't talk, and they do repetitive hand flapping, and they toe walk. [41:47 - 42:19] So mercury is known to cause this this feature if you ingest it, why not if you inject it? Okay, so we can get into the mercury, issue with Burbacker in a little bit that's coming up. People misinterpret Burbacker or don't interpret it at all. There there are examples of environmental liability that have been published, this is all public record, mercury amalgam increases the risk of maternal immune activation, there are too many sources to list. Acetaminophen after MMR, there's some survey studies and so on that show that. [42:20 - 43:07] Autoantibodies, brain autoantibodies are increased in kids with autism and in mothers with autism. That should tell us something, that maybe through pathogenic priming we're causing autoimmunity that causes the brain to actually experience some problem. Not sure that it's antibody based, but somehow the brain system has an immune system there, so serum levels of vitamin D are associated with autism risk. So we can't come up with an autism risk model and say that these kids are at risk of autism, put these kids on this side of the room and don't vaccinate them and see if their autism does not manifest like Doctor. Paul did, and he had so few cases of autism, we couldn't include it in our study of four thousand three thousand five hundred kids in Oregon. [43:10 - 44:07] Yeah, and so for people to say there's no evidence of any risk of autism, there's actually a huge number of studies now. This is early on really, that, the preliminary study found that acetaminophen use after measles mouse for bowel vaccination was associated with autistic disorder. This has been replicated many times over. What happens is that kids get the vaccine and in an abundance of caution, the doctors are saying give them acetaminophen before they get the vaccine. So they get the vaccine, they already have acetaminophen, they get a high fever, the parents give them more acetaminophen and so you've depleted the glutathione and so toxins that are either with the MMR things that were co administered with the MMR potentially out to aluminum containing vaccines or mercury containing vaccines then have a chance to go to work along with any of the autoimmunity with anti brain proteins. [44:07 - 45:10] So that's a mess. I can't really show you this, but yeah, there's other studies of Ella Garcia. So I would say it's no more than 50% genetic, autism is no more than 50% genetic, and it's at least 50% environmental, and it's likely more, because if you actually did the study that we should do, we should end up with genetic times environment, a genetic plus environment times genetic by environment, or genetic multiplied by environment, and we don't have that interaction term. And so you can play statistical games and just do genetic studies, just do environment studies and never show the interaction term and say, wow, it's not just environment, but the environment is interacting with genes so badly that we really need to consider screening kids. Here's a map of what I call the in the book, the environmental toxin liability sampling theory, and that kids that are already at risk of having problems either detoxifying or having problems with neurodevelopment already have an ambient amount of toxins from the environment, just like everybody else. [45:11 - 46:26] So you have specific genes here and you have different categories of kids with even just one gene or two gene variation, but then if you add in the 17 shots with aluminum before year two, you're adding a consistent repetitive dose of ER stress to these kids. So what I'm saying is that depending on your genes, you might be more tolerant of different toxins in the environment, and I think that as we continue with Western civilization and our chemistry, our our our oil based, petroleum based compounds that we put into our food and our water and our clothing and our medicines and so on. I think eventually we would have had an autism epidemic. It would have happened later, but you keep adding chemicals to the environment, you're gonna find everybody that can't tolerate those particular chemicals leading to ER stress. I wanna talk about Burbacher at all because I actually this is what impressed me early on about Robert F. [46:26 - 47:11] Kennedy junior. He has a book, Thimerosal, Let the Science Speak. And in this study, Rhesus macaque monkeys were exposed to injected Thimerosal, which is 50% ethyl mercury by weight, and they were also exposed to environmental mercury or methyl mercury. And they actually tried to model the clearance of the organic form of mercury that was left behind from methyl mercury and they succeeded in doing that. The inorganic form that was left from ethyl mercury stayed in the brain so much that their model showed that they could they did not expect it to clear at any time in the future. [47:11 - 47:32] And you I bring this up because oftentimes people will say, well, you're confusing ethyl mercury and methyl mercury as if the toxicity of methyl mercury exonerates ethyl mercury. Right? So, like, I would say rubbing alcohol is safe because gasoline is dangerous. Right? It doesn't make any sense. [47:32 - 48:23] You could still start a house fire with us with with with rubbing alcohol. You see, it's it's a non sequitur argument, and so Burbacher et al set this straight. And ipac-edu.org has information sheets that break down mercury, that break down aluminum, and all the literature there. This is probably one of the most important papers that supports the position. I mentioned it earlier, but they actually screened for no particular reason, the ACS medicinal chemistry letters, no particular reason they wanted to screen what the effects of thimerosal might be and they found that it inhibits ERAP1, well ERAP1 it turns out and ERAP2 are very homologous immunopeptidases that are important for proper protein folding in the immune system, but elsewhere as well. [48:25 - 50:20] Rooney looked at inorganic retention in the brain. I looked at the schedule with aluminum and and modeled it based on clearance studies, I published three papers on it with colleagues, including Paul Thomas. It turns out that after you correct for kidney development, kids on the CDC schedule in 2016, sorry, for 02/2008, it hasn't been that long, 02/2010, kids on the CDC schedule in 2010 were in whole body aluminum toxicity above my pediatric dose limit, which I published in 02/2008, based on body weight, assuming that eight fifty micrograms is safe, I take the FDA's word for it, for an adult, because all the studies that were done on aluminum were done on adult mice, but they were, I don't want to get into it, they were fed aluminum and they did some math and said this means this is similar to the amount of, they had a transformer, they had a transform equation that they said, well, if it stays in the body this long for diet, then this is equal to injection, but my studies actually throw out yeah, so my study is in aluminum throw out the FDA's paper by Mitkus et al, that used data from oral forms of aluminum, like citrinalated aluminum, fed to adult mice as a substitute for data for injected aluminum into infant mice, in part because of the logic of their study, was just horrible, but also we updated the kinetics of it to look at the clearance and the accumulated dose. [50:20 - 50:47] They just wanted to determine whether it's what what a single dose toxicity was, and we actually calculated the the cumulative dose and compared it eventually to the pediatric dose limit that we had published. So we could say you're putting kids in whole body aluminum toxicity. Aluminum is not supposed to be in the body. It's supposed to be in the earth's crust and bauxite. No living system evolved any use of, aluminum that I know of. [50:47 - 51:53] Chris Shaw sites a plant that might have some silica like aluminum use in its stems, but I don't know about that. So at the time you were looking at five thousand seven hundred and seventy five micrograms in a typical schedule in the first couple of years of life, and our studies which I'm not going to go into much here, have the curves and show that, yeah, we're not clearing the aluminum out enough to be below the pediatric dose limit. Yeah, so in the paper, sorry, in the in the book, I cite the studies that found that aluminum causes a buildup of glial fibrillary acid filaments near the cell nucleus and destruction of the active cytoskeleton. I mean, is a cellular toxin like you wouldn't believe. So going back to the environmental toxin liability sampling theory, now add into those repeated instances, each one of them causing endoplasmic reticulum stress, you can see why I glommed onto this as a likely important cause, from the mechanistic level. [51:56 - 52:25] Aluminum does induce ER stress, so the literature is there to support it and it's independent of p 53, it's actually necrotic cell death not apoptotic. So I mentioned this earlier, but when they say no study is ever shown, they analyze the data repeatedly till the positive association goes away. They will change the results post peer review in plain sight. There's one study that actually changed the results after it was published, and the NCBI allowed them to change it with no notification. It's crazy. [52:27 - 53:22] There's a bunch of statistical tricks that they can use. Correcting for covariates is one of them where they correct her mother's age, mother's income, they correct for gestational weight, gestational age, all on the same model, all four of those things as if they don't know about collinearity and the problem is for model overfit. What they're doing is they're throwing all the potential confounders that they can throw in there into the soup to see what makes the association go away, and then they publish only the final result as if somehow they were guided by the hand of God to know that these were the variables. Well, I I happen to pay attention during my, multivariate and, you know, classical regression, course, when we were taught that there's formal model selection criteria like IKEA information criterion or MalloCP. I've never seen any of these people doing any of this. [53:24 - 53:58] Or you could do model selection forward, variable selection, or backwards. You could you could do actual feature selection and machine learning. They don't don't do any of this. They're doing basically nineteen eighty five type of social clinical association sorry, population level association analysis on on what should be done very, very cautiously and carefully in terms of model selection, and it's cheating. And furthermore, at the top of the presentation, I said there, you know, some studies some vaccines have never been studied for for vaccines in autism. [53:58 - 54:46] I know because I looked, I looked at this published peer reviewed scientific literature, and I found that there actually were some studies that were conducted for some vaccines that showed positive association, and so I've been trying to tell people that they're ignoring, they're cherry picking. They sent president Trump a list of studies he they didn't know he already had a copy of my my book on his desk in his first administration. There are studies that show association, so they're outright lying. They're choosing to ignore it. Ginger Taylor has a wonderful resource, I think it's called howvaccinescauseautism.com or something, where she's been curating these studies and she's doing a great job, but you can't say vaccines don't cause autism unless you've studied pneumococcal conjugate or inactivated polio virus. [54:46 - 54:59] Well, that's not really in use, right? So, influenza, no one's ever studied the influenza. You have sixty percent of influenza vaccines contain ethyl mercury to this day. One's ever studied it. Okay. [54:59 - 55:13] Rotavirus, no one's ever studied it. They studied MMR, Deterior and Haemophilus influenzae, varicella and hepatitis. This is not a massive amount of studies. Right? But these studies show association too. [55:13 - 55:47] Okay? So they're absolutely just lying. And I could go into how they lied to the IOM, you know, year after year, you know, report after report and how the IOM was affected by CDC, Walter Orenstein intruded, how the IOM one year said that there was not enough information to make a determination one way or the other, and one person went out and did a press conference and said the opposite. They said that they determined one of the opposites. They said that they had sufficient to determine that vaccines do not cause autism. [55:48 - 56:00] Okay. That was Barbara Cormack. Doctor Barbara McCormack did that. So I know the history, we know we know who the bad guys are so to speak. Aluminum is not available in nature. [56:00 - 56:22] It doesn't belong in in being injected. It doesn't belong in food. It was called generally regarded as safe, but there are thousands and thousands of studies that show that, aluminum is a potent neurotoxin. People say it's not a problem because it's the third most common, you know, element in the Earth's crust, but that's where it has been all for all of life. Right? [56:22 - 56:46] Until we decided to dig it up as bauxite in the eighteen fifties and isolate aluminum, it didn't affect any living thing really for the most part. And so it being common and being safe are not the same thing. That's a fallacy. That's a common equal safe fallacy. And yet we put it into food and then we started injecting it into people as if it's something that's okay to inject. [56:48 - 58:10] As I've said now, this will be the third time aluminum hydroxide itself is used to routinely and reliably induce autoimmunity in pharmaceutical model animals so that they can, you know, cure asthma in mice and sell the drugs to the public. So I'm not gonna go into the whole Kabuki show, how they went from dietary aluminum to vaccinated in the Mitkiss study, but it was horrible. They they did do they cherry picked one study, and we the first thing I did when I created iPAC was I went through with doctor Rickettsson, we went through the entire literature to find out how they determined that eight hundred fifty micrograms of aluminum was safe. And we found that after studying all of these studies of oral forms of aluminum, they actually had to cherry pick one study, and they said there is one study that shows that this amount fed, that we could mathematically argue that is equal to this amount ejected, that had no adverse events. But that was a lie too, because that particular study called the Golub study, they had cyclical feeding and those mice had cyclical feeding, and cyclical feeding is a symptom of toxicity and problems of neurodevelopment in the mice that were used. [58:11 - 58:51] So, yeah, if you go to my study in 02/2008, the first time that we, you know, published the paediatric dose limit, I went through, we went through and we took that entire argument apart. We know what the quote unquote safe level is, four to five micrograms per kilogram per day. We know based on body weight that eight hundred fifty micrograms is too much for kids. They know it too, which is why hepatitis B only has two hundred fifty. The two fifty is still fourteen times the dose that they should get, fifteen times the dose that they should get if you correct for body weight based on age. [58:53 - 59:17] Yeah, there's some regulatory issues here too. So under FDA's rules, and this has to change, you only have to test the safety of the proteins. You're not required to test the safety of ingredients, preservatives, dilutions. They shall meet generally accepted standards of purity and quality. You don't have to test aluminum for safety. [59:17 - 59:43] And then they put these limits, this is where we got the eight fifty micrograms, eight fifty micrograms being the smaller of the three doses depending on how it's measured for our studies. So keep going. This is the kind of, this is Midkiss, the study that I took apart. There was disagreement between the two communities. There's the cherry pick study delayed. [59:44 - 01:00:08] It's oral exposure. It's just a mess what they did. I'm not going to go through all of this. I have to save some time. And this is from our paper, published paper in 02/2008, and if you look at body weight informed FDA dose limits by age for an adult, you can see that it's much, much smaller for children. [01:00:08 - 01:01:41] That was our first attempt at a PD L and you can see that the pediatric doses in children, once you correct for body weight, are much, much higher than the doses in adults. This is, go ahead and read that paper for those details, but this is, this is bad. I think this is our first plot that showed that the PDL curve, which is the blue curve, and the ninety fifth percentiles, upper body, lower body weight, that we see multiple acute instances of high toxicity of aluminum from the vaccine, and then we also see that it persists and, you know, like I said, we updated that PDL so that in the first two years of life there's a drop off in the PDL because of that the kidneys are not fully clear. So even in this result, kids in the first year, seven months of life are are in an aluminum toxicity, whole body aluminum toxicity, a 100% of their days, with unknown effects on neurodevelopment because it hasn't been seriously studied. And then we took on we took on this guy, Paul Paul Offit, who's fond of saying, you know, you you'll get more aluminum from anything that you eat made of water or or, you know, anything you eat. [01:01:42 - 01:02:41] You know, and and if you look at the appendix of our I think it's our second study, we actually show because almost a 100%, like 99.7% of aluminum that you just passes through the body without getting into the, you know, the system at all. You can eat far more aluminum safely than you could ever inject, but a 100% aluminum that gets that's injected has to be dealt with. And so when he says that it's we we have an appendix, like I said, that that disproves this arm waving that Children's Hospital of Philadelphia says, I think it's misleading the public. The dietary aluminum varies, with age, but it's also kind of silly to say you get more aluminum for food than you do for vaccines. Aren't you concerned about cumulative exposure? [01:02:42 - 01:03:16] It make sense to say, hey, hey, what is the effect of injecting kids when they're already eating aluminum? And we should work out. So YOCO at the University of Kentucky is the source if you want to go look at the best source for the ingested forms of aluminum, and we put this table together, percent increase in aluminum. Yeah, don't think we ever published this one, but alright. So if you look at Paracelsus in 1538, it said the dose makes the poison. [01:03:16 - 01:03:43] If you look at James Lions by the 02/2017, body weight makes the dose makes the poison. I can't believe I actually have to remind CDC that babies are not a hundred fifty pounds. That's my point. Their toxicity assessment the FDA's toxicity assessment for MYCUS was for eight hundred fifty micrograms, but they never did anything about children. And then they packed the pediatric dose full of aluminum container vaccines. [01:03:43 - 01:04:23] IPAC published the world's first pediatric dose limit for children, and then we had to update it because of the kidney. Mirza, Chris Exley, King, and colleagues, they actually found a high amount of aluminum in Alzheimer's brains, full localized with the neurotropism associated with Alzheimer's, amyloid deposits. Well, I'm not surprised by this result. It turns out that amyloid in the brain is amyloid precursor protein plus aluminum plus silica. This was published in 1985. [01:04:23 - 01:04:49] So to say that aluminum is not a problem, and we know that there's aluminum in the brain of kids, people with Alzheimer's, we know that initially autism was called infantile Alzheimer's. We know that aluminum gets into the brain. There's no doubt that it gets past the blood brain barrier. We knew in the nineteen eighties and nineties not to cook in aluminum pots anymore because there's association with Alzheimer's. Did we forget that kids have brains too? [01:04:51 - 01:05:01] Okay. So this is what it's like to watch the media say, hey. This is what's going on. Alright. There's nothing going on. [01:05:01 - 01:05:51] No problem whatsoever. I think we have a better way and they don't want to hear about it. Here are these cavemen that are dragging their rocks with a wagon that has square wheels and to see all of the agencies and to see all of pharma and all of medicine, basically all of allopathic medicine and all of society yell at each other, vaccines don't cause autism, you're crazy to say vaccines cause autism, And there's this one guy that comes up and says, hey, wait a minute. I've got something better than square wheels, and they just completely ignore it because they would have to actually then admit the liability. If we can show that we can predict who has who's going to develop autism and prevent it, that's more powerful than any association study, and that's what we really need to do. [01:05:54 - 01:06:18] So just remember, aluminum levels of vaccines, according to our peer reviewed publication, are unsafe. We need risk factors and biomarkers. We need to do vaccine safety screening specifically to say these kids should not get vaccines. And if we do that, we'll be doing them a world of good. Like I said, I think autism would happen without vaccines, but it would take a lot more toxins to do that. [01:06:18 - 01:07:02] But this is when I was at the Hard Rock Cafe in Pittsburgh, Pennsylvania celebrating my book release with a bunch of kids with autism on stage with me playing guitars and banging on the drums, a guy pops up at a break. It was, Scott Faber, and he shows me this his phone and he says, does your book have this figure in it? And I stepped outside and I called Tony Lyons at Skyhorse and I said, you need to stop the presses, I have to add this. It had just published, I have to add this. What this particular study means serum level common organic pollutants is predictive of behavioral severity in children with autism spectrum disorder shows. [01:07:02 - 01:08:00] Well, first of all, I should tell you this same team took a, like, a dozen kids with autism and that had high a dose scores, put them in a clean room for twenty four or forty eight hours, and when they were in a clean room and moved from toxins, ambient toxins in the environment, their a dose scores got got less, reduced. A control group that were left outside, you know, in in a room that wasn't a clean room did not get any better. But what this shows is they they they took serum concentrations of organic pollutants, like from plasticizers and from gasoline and and, stuff that's found in, fertilizers, pesticides, and flame retardants, and they looked at the mean serum concentration and the ADOS score. So the y axis here is the ADOS score, higher the ADOS score, the worse the behavior, they're having a bad day, the lower the ADOS score, the better the behavior. Then it took a control cohort of kids, did the same study. [01:08:00 - 01:08:43] First of all, the control cohort doesn't have high levels of organic pollutants, whereas like I said, the kids with autism can't detoxify nearly as well, so they're holding on to the toxins. This is a problem. They have detoxification deficiency, and Scott actually, this this to me shows that if you can reduce the exposure to all kinds of toxins, that that it's pediatricians should be telling parents of kids with autism, get your gasoline out of there, get plasticizers out of your house, don't have any organic solvents, Don't have anything with mercury. Don't have any pesticides around the house. Keep them off of the playground if it's been sprayed. [01:08:43 - 01:08:56] Tell the people to school to get the pesticides out of there. Probably keep fluoride out of their diet. Right? And don't let them have be exposed to flame retardants. These kids will be able to focus better and do better academically. [01:08:56 - 01:09:22] They'll have better days. They'll have a more pleasant human experience, and and it really annoys me that this was published long ago. We don't have any change in policy to improve these kids to ACE. This is also from the same study and you can see that there's a shift in different kinds of toxins, some of them are higher in the controls than in the ASC. ASC. [01:09:24 - 01:10:10] So the specific compounds that we should have them. Chlorophyllous actually found to be associated in New York State on a per hectare basis of increased incidence of autism in counties that dump more chlorpyrrhosis than others, and so it was banned in New York State. Chlorophyllous I think was up for an EPA ban, but I don't think they, I don't think it lasted, so they have been in effect for a little while. So we have a problem with being able to let go of the toxins that we know are causing neurodevelopmental disorders. And then I mentioned the anti brain antibodies, molecular mimicry, pathogenic priming. [01:10:11 - 01:10:54] Many mothers now report being vaccinated during pregnancy. We need to study vaccination during pregnancy. We know the CDC, especially Tom Shimabukuro, has, you know, left out important results like, I think it's over four thousand times increased risk of fetal demise in women that got the flu vaccine, and that I don't think it was subdivided into influenza with thimerosal versus influenza without. So we know the mechanisms, got my top of these, you got chronic microbial activation, Russell Blaylock calls that excitotoxicity. We have channelopathies that people know about that are involved with, what's a channelopathy? [01:10:54 - 01:11:32] Well, that's the inability to move things around the cell. Well, no kidding, look at what these toxins do. We have molecular mimicry, so there's some aspect of autoimmunity there and then we also have encephalopathy, which is actually not a mechanism, it's an outcome. These are the pyramidal cells sections of the autism patient versus not, and you can show that they're relatively simplified. If this is severe, then the person will be a simple person, that is to say just like in Alzheimer's, at an old age, the semisance of the simplification makes them more childlike in in their cognition. [01:11:34 - 01:12:02] But that's not true for all kids with autism. At the time I wrote this book, said we need to presume that they're there. We need to presume that a kid in the classroom is learning because God forbid, God help us if we're teaching them all this stuff and then they know what we want them to know and they can't use it in any way because nobody bothers to ask them. Well, the spellers program has changed that completely. There are geniuses that taught themselves or learned calculus ahead of the other class. [01:12:02 - 01:12:45] There are poets, there are fine, fine people, you know, very forgiving people too, amazingly, that come through the spellers program and they understand that their parents just didn't know and society didn't know. You think they'd be angry and so on, but they're just grateful that they can now speak and order the what they want for dinner, you know. So we have to promote the spellers program And there's there's research that's going on, but looking at large scale gross associations and correlations, that's done. That that period is done. That's not going to teach us anything more than we don't already know. [01:12:45 - 01:13:58] We need to drill down into the subtypes, we need to drill down into toxic exposures, not for causality, but to know how can we begin to actually prevent, And, yeah, I'm not gonna go through all of this. I I like I said, I can tell you everything about the IOM, but I'm it's all in the book. We now have a problem and we know what the risk factors are, we could screen using genes like this and there's other ones, these are the specific autism genes, but there's also other ones like COMT, MTHFR, if it's not there already. But there's a course that we teach at iPackEDU called Genes and Vaccines, and these are genes that actually help some people who practice psychiatry, ethical psychiatry, to help kids find pathways to health by avoiding certain things in their diet and their exposures based on their genetics. So it is actionable, it's clinically actionable, we just have to have regulatory approval. [01:14:02 - 01:14:28] The NICU is an entirely different story. These kids are basically 2.2 that give them, supposed to give them half a dose of the hepatitis b vaccine. Some cases, I'm told by nurses, they're still getting a whole dose. And then they they bring in, in The United States, crash carts, vaccinate all the babies at once because they know some of them are gonna have heart problems, some of are gonna have encephalopathy, some of them are gonna have breathing issues. What for? [01:14:28 - 01:15:07] For hepatitis b, forget about it. I already mentioned Bowers, but I did do a pathway type analysis, and the genes that are associated with these particular environmental concerns, some of them are immune systems, some of them are axon guidance and some of them are signal transduction. So it's multifactorial even in its implementation and its effect. In The United States, you know, we have the National Childhood Vaccine Injury Act, and, the Supreme Court ruled that vaccines are unavoidably unsafe. I don't think that's true. [01:15:07 - 01:15:25] I think we could take out unsafe epitopes. We don't have to use adjuvants. We could use microneedle patches with vitamin e type crystals. I don't have any intellectual property there. But it's kinda like if you're gonna work in the federal government, you have to swear that vaccines don't cause autism regardless of where you're working. [01:15:26 - 01:15:48] Mary Holland and companies found, eighty three instances of diagnosis of autism and award cases from the National Vaccine Injury Compensation Program after they said they weren't, awarding. So they looked at the symptoms. They had doctors looking at the symptoms of the cases, they said this kid had autism. They're giving awards for encephalopathy. Yeah. [01:15:48 - 01:16:27] This is something else, but, you know, there's this in twenty sixteen, seventeen, pharmaceutical companies funded the Democratic National Convention, the Democrats to strip parents' rights of all types of philosophical exemptions and religious exemptions as if a 100% vaccination is going to do something more than ninety ninety ninety nine percent. And we fought that. There's a good paper here by Ophimios Cardodisius. He's from Ohio State University. He's got a master's in bioethics. [01:16:28 - 01:16:50] And he looked at, in The United States vaccine refusal constituting neglect. Well, they don't understand what I understand. If a parent has a problem with a vaccine with a child, what parent in the right mind is going to say, oh, okay. Let's do that again. They have clustered or special risk. [01:16:51 - 01:17:08] They have idiosyncratic risk. This means that they're and it's identifiable. That means under The US constitution, as it is right now, with its amendments, they're entitled to equal protection under the law. That case has not been argued. So I have some good ideas on how we can proceed. [01:17:08 - 01:17:26] They don't all just surround around proving vaccines cause autism because I'm well beyond that. I'm ready to go and change policy. I'm ready to go and change medical practice. But some science has to be done. We have to show that we can actually screen people away from the vaccine program rationally and get them out of harm's way. [01:17:29 - 01:18:09] Yeah. I'm not gonna go into the whistleblower. There's a whole movie out now about this. On efficacy, I don't I don't think that's the point for today. This is just to remind you that when they called for public comments on the MMR vaccine information sheet, a colleague of mine, Bernadette Pager, and I actually made public comment, and the FDA refused to publish ours and they refused to publish 75 other public comments until we got a lawyer and we reminded them that in America we have The United States we have the first amendment. [01:18:10 - 01:18:38] They returned they published ours, but it was redacted. And I'd like to find out who did this, and I'd like to have that person's head on a plate, to speak. They actually unredacted it and published it again this way after we sent them a second letter. But I was actually harmed by this and the public was potentially harmed by this. It was wrong for them to censor me under the US constitution. [01:18:38 - 01:18:58] I would encourage every country in the world to have a first amendment, equivalent. So, yeah, I, gotta make sure we're plugged in so we don't die for question and answer, but that's coming soon. Let's see. Alright. Give me one second, guys. [01:18:58 - 01:19:23] My battery's threatening to die. But, yeah, you know, we we actually published another one in and and put and put our comments on the same person. Must have been tasked with making sure that we aren't scaring the public out of an abundance of good. These regulators that are doing such good work there. Imagine if they had to report to Elon Musk what they did this week. [01:19:23 - 01:20:02] You know? I I don't think that that that would float to to report to those that they were violating first amendment rights of US citizens for a living. The redaction itself included Doctor. William Thompson, one of the researchers on the dystrophin overall study mentioned above, came forward in 2014 as a whistleblower on the study stating results that did in fact show causal link between the timing of administration of MMR and autism were removed prior to the presentation. And I know they were removed because I have copies of the presentation that Frank Di Stefano presented and a copy of the presentation that William Thompson gave him. [01:20:04 - 01:20:43] So, you know, it's a battle. It's not even ideological, it's economic. This is purely an economic battle. This is an industry that wants to rule through government, with the power of government over people as if they have the right do so. And I think I'm the first person to point out that vaccine safety studies, long term vaccine safety studies, post market pharmacovigilance, they call them, are a form of human subjects research, and no one has ever been consented for long term vaccine safety, and that's a violation of the principles of informed consent, 44 CFR 45. [01:20:46 - 01:21:15] IPAC Edu now has I'm an expert in this. IPAC has its own IRB now. So, yeah, you you can take a look at more of what I've wrote about vaccines and autism at jameslinesweiler.com and also at popular rationalism substack. A lot of people have said a lot of things, but I think you get a feeling here that this is not about manipulation of risk or managing risk. This is just about manipulation of the perception of risk without actually minimizing risk. [01:21:16 - 01:21:35] Okay? And so there's some some some irresponsible and reckless things here that are are indicative of the scale of the problems. Yeah, so we need to take a look at what we're doing with research. Do we need studies that show the vaccines cause autism? I don't think so. [01:21:35 - 01:22:11] I think we need to start acting on getting people out of harm's way specifically, so that when retrospect we say, oh, they would have developed autism. Look at the autism rates are going down in the people in this study. We need a 100,000 people that are not vaccinated, kids that are not vaccinated based on their genetic profile, and look what happens to the autism rates in them, you know, compared to kids who they are that are vaccinated that have the same genetic profiles. That would take about four years. And, yeah, just understanding it all matters. [01:22:11 - 01:22:37] It's multifactorial. It's complex. I did a deep dive. It took me four months to read all of it. But, know, we, neurodevelopment is extremely important for human health, it determines where you're going to be in life and what you're going to do, but there are many, many other conditions that are associated with vaccines that we can't ignore either, and they're also equally important in disease burden. [01:22:37 - 01:22:58] Many of them are chronic illnesses, and that's why Robert F. Kennedy Jr. Where he is. He's promising through BAHA, he's promising to use the new HHS to reduce chronic illness and bring this to an end. Unfortunately, these kinds of illnesses are $3,400,000,000 profit center for allopathic medicine. [01:23:01 - 01:23:34] Yeah. In 2017, vaccine risk awareness was a term that I coined along it was kind of along with pathogenic priming. Coined that term too. But I see people on the vaccine risk awareness, not the vaccine refusal vector, or if you will, this is a different dimension where vaccine refusal is an act, but vaccine risk awareness is a person's state. So rather than characterise somebody by their act, let's characterise them by characteristics. [01:23:34 - 01:24:02] It's more proper in category theory, and it's also more respectful of the fact that people can move up and down on this. Almost everybody that moves up in towards towards higher vaccine risk awareness, they hardly ever move back backwards on it. On the left, see the trolls in the marketing department for pharma that refuse any vax and and that includes every single marketing department, whether it's a formal marketing department or not. This is powerful. Like, words have power. [01:24:02 - 01:24:42] And I would argue that rather than arguing about anti vaccine or pro vaccine, we should counter with, well, I'm vaccine risk aware. What does that make you? Departed friend of mine, a dear departed friend of mine, doctor Tony Bark, who passed from cancer, said we can take on this language issue where an anti vaxx says I want to ban all vaccines, vaccines can never be made safer. In VRA, vaccine risk is real and should be minimized. She used to say, if you believe that those who are vaccine injured are anti vaccine, do you also believe that those who are injured by faulty brakes are anti brake? [01:24:43 - 01:25:00] I mean, it's non sequitur. We can use standard logic and we can free the language to be able to speak with reason. That's why I created Popular Rationalism. That's why I created Epic EDU. You know, we have a long ways to go, but we at least have keys to the castle. [01:25:00 - 01:25:43] So this is not new, in 2008 there seemed to be genetic susceptibility, it admitted to by the then director of the CDC, Bernadine Healy. She said that mitochondrial dysfunction might set some kids up for autism. Yeah, I think there's a pathway towards safer artificial immunization. I'm not married to the idea, I don't want to make my money off of doing it, but there are some better things that we can do that they're not doing. Identifying genetically susceptible subgroups, I've said that now a few times and there are multiple programs that I can envision. [01:25:43 - 01:26:06] This is where I think we might be at. Seventy five to ninety seven percent have no risk or truly minimal risk. It's the three to twenty five percent of the population that are identifiable. We could go as high as twenty five percent autism on the current vaccine schedule because other toxins are coming in too. So something's got to give. [01:26:06 - 01:26:40] No one wants to own the liability, but we I don't care about liability. What I care about is stopping from ruining people's lives with great deal of respect for every person that has autism. Their lives are ruined in the sense that they can't participate to the same degree that they would have if they were not altered by toxins intruding into their lives. I believe that they're not misbehaving, they have autism and please be understanding, you know, this is not an indictment of autism. What it is is hope for the future that we can do better. [01:26:42 - 01:27:24] And I'll close with Calvin and Hobbes, do you think it's better to live in stupefying security or to take risks, Calvin says, and live life on the edge? Calvin says, I think it's better to accept danger and live life to its fullest. And then you say, he says to Hobbes who's not there, I take it by your silence that you agree. So as people slide down the hill of risk, we don't have to join them. If you go to avengecauses.com, you'll see the references, you might have to go to the Wayback Machine to find them though, but this was the website, for this time for some reason, I've got to get it back up, but they're all there and I can have, I can send the references to anybody who wants them. [01:27:25 - 01:27:43] Just remind you that autoimmune diseases are exploding and we can do better. We need to reduce autoimmune disease by cutting out aluminum, and that's probably more than enough for today. Allergy, chronic disease, yeah, you've seen this here, so thank you.